BDBM50209758 CHEMBL3884143
SMILES Cn1cc(Nc2ncc(Cl)c(Oc3ccccc3NC(=O)C=C)n2)cn1
InChI Key InChIKey=QXQGHCJUTRTRLJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50209758
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of full length recombinant human GST-tagged ERK2 expressed in Escherichia coli using Ser/Thr 03 as substrate after 1 hr by Z'-Lyte assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase 7(Human)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of TAK1 (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair