BDBM50204694 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE::3-(4'-hydroxy-biphenyl-4-yl)-1,4-dihydro-indeno[1,2-c]pyrazole-6-carboxylic acid (trans-4-hydroxycyclohexyl)-amide::3-(4'-hydroxybiphenyl-4-yl)-N-((1r,4r)-4-hydroxycyclohexyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide::3-(4'-hydroxybiphenyl-4-yl)-N-(trans-4-hydroxycyclohexyl)-2,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide::CHEMBL438485

SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)c1

InChI Key InChIKey=VKPCXCHYSBVEMW-UHFFFAOYSA-N

Data  1 KI  17 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50204694   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SRC by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataEC50: >5.90E+4nMAssay Description:Antiproliferative activity against human SW620 cells by soft agar assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of SGKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 8.09E+3nMAssay Description:Inhibition of aurora 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 4.43E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 8.09E+3nMAssay Description:Inhibition of Aur1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDC2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MARKAP2 kinase by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CHK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EMK by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ERK2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataEC50:  2.52E+4nMAssay Description:Antiproliferative activity against human SW620 cells by soft agar assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of SGK by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKCdelta by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C gamma type(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of PKCgamma by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 4.43E+3nMAssay Description:Inhibition of AKT by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant CHK1 assessed as human Cdc25C phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of G2/M cell population in human H1299 cells by FACS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PKA by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed