BDBM50192809 CHEMBL3941914
SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2C3CCC2CN(C3)c2ncc(cn2)C(F)(F)F)n1
InChI Key InChIKey=JARXMNZSCUFQHX-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50192809
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rat)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human TRPV4 expressed in CHO cells assessed as inhibition of capsaicin-induced responseMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human TRPV4 assessed as inhibition of hypotonicity-induced activationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rat)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of hypotonicity-induced activationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of hypotonicity-induced activation pretreated for 5 mi...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Rat)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Shionogi
Curated by ChEMBL
Shionogi
Curated by ChEMBL
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at recombinant human TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins ...More data for this Ligand-Target Pair