BDBM50188913 CHEMBL213618::N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide::N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE

SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl

InChI Key InChIKey=HHOVRZGUSBMKKU-UHFFFAOYSA-N

Data  13 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50188913   

LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  320nMAssay Description:Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 66nMAssay Description:Inhibition of PKCaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  370nMAssay Description:Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RAF1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Chiron

Curated by ChEMBL
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 400nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed