BDBM50183448 CHEMBL3823478::US11773085, Compound B2
SMILES COc1cc(cc(OC)c1CN(C)C)-c1cn(C)c(=O)c2cnccc12
InChI Key InChIKey=RBUYFHLQNPJMQM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 35 hits for monomerid = 50183448
Affinity DataKd: 121nMAssay Description:Binding affinity to recombinant human His-tagged BRD7 (129 to 250 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 0.75nMAssay Description:Binding affinity to human BRD9 isoform 1 by BROMOScan analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BRD4-BD1 by alpha assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human BRD4 isoform long, bromodomain 1 by BROMOScan analysisMore data for this Ligand-Target Pair
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to human BRD4-BD1 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Inhibition of human BRD7 measured after mins by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.300nMAssay Description:Binding affinity to human BRD7 by BROMOScan analysisMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constant by SYPRO orange dye based differential scanning fluorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 9.40nMAssay Description:Binding affinity to recombinant human His-tagged BRD9 (134 to 239 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: 187nMAssay Description:Binding affinity to human CECR2 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair
Affinity DataKd: 0.316nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 0.794nMAssay Description:Binding affinity to BRD9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Displacement of FAM-labeled BI-FAMb from N-terminal His TEV-tagged human recombinant BRD7 bromodomain expressed in Escherichia coli BL21(DE3) by comp...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Displacement of FAM-labeled BI-FAMb from N-terminal His TEV-tagged human recombinant BRD9 bromodomain expressed in Escherichia coli BL21(DE3) by comp...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of NanoBRET BRD Tracer-02 from Nanoluc-fused BRD7 bromodomain (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRE...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of NanoBRET BRD Tracer-02 from Nanoluc-fused BRD9 bromodomain (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRE...More data for this Ligand-Target Pair
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Binding affinity to human BRD9 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Inhibition of human N-terminal GST-tagged BRD7 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScreen ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD2-BD1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD4-BD2 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged BRD4-BD1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScr...More data for this Ligand-Target Pair
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of ACVR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 8.80nMAssay Description:Binding affinity to human CECR2 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by BROMOScan analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of ACVR2B (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 275nMAssay Description:Inhibition of BRD9 in mouse RN2 cells assessed as decrease in cell proliferation by cell titer glow assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes in presence of NADPH using amodiaquine as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes in presence of NADPH using diclofenac as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes in presence of NADPH using mephenytoin as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes in presence of NADPH using midazolam as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes in presence of NADPH using dextromethorphan as substrate measured within 2.5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of FAM-labeled BI-FAMb from N-terminal His TEV-tagged human recombinant BRD9 bromodomain expressed in Escherichia coli BL21(DE3) by comp...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Displacement of FAM-labeled BI-FAMb from N-terminal His TEV-tagged human recombinant BRD7 bromodomain expressed in Escherichia coli BL21(DE3) by comp...More data for this Ligand-Target Pair