BDBM50178612 (S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide::4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide::CHEMBL206834::N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-4-{[(3S)-3-(DIMETHYLAMINO)PYRROLIDIN-1-YL]METHYL}-3-(TRIFLUOROMETHYL)BENZAMIDE

SMILES CN(C)[C@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1

InChI Key InChIKey=ZGBAJMQHJDFTQJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50178612   

TargetTyrosine-protein kinase ABL1(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50178612(N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Abl kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50178612(N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Lyn kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
The First People'S Hospital of Hangzhou

Curated by ChEMBL
LigandPNGBDBM50178612(N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BCR-ABL kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
The First People'S Hospital of Hangzhou

Curated by ChEMBL
LigandPNGBDBM50178612(N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of BCR-ABL (unknown origin) in presence of [gamma33P]-ATP and ATP by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Nippon Shinyaku

Curated by ChEMBL
LigandPNGBDBM50178612(N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]-ATP and ATP by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed