BDBM50164794 CHEMBL3798846::US11174250, Example Table4.1.1::US11319299, Comp. No. 57
SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1
InChI Key InChIKey=DJOVLOYCGXNVPI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50164794
Affinity DataKd: 30nMAssay Description:Binding affinity to human poly His-tagged WDR5 (1 to 334 residues) expressed in Escherichia coli BL21(DE3)-V2R-pRARE2 cells by surface plasmon resona...More data for this Ligand-Target Pair
Affinity DataKd: 93nMAssay Description:Binding affinity to His-tagged human WDR5 expressed in Escherichia coli BL21 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
TargetP61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534](Human)
Propellon Therapeutics
US Patent
Propellon Therapeutics
US Patent
Affinity DataIC50: 9.50E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Affinity DataKd: 36nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Affinity DataKd: 30nMAssay Description:Binding affinity to poly histidine tagged-human WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3)-V2R-pRARE2 assessed as dissociation...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Competitive inhibition of WDR5 (unknown origin) assessed as inhibition constant in presence of 5-{[(5S)-5-(6-{6-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carba...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Binding affinity to WDR5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Competitive inhibition of WDR5 (unknown origin) assessed as inhibition constant in presence of 5-[({2-[2-({[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2...More data for this Ligand-Target Pair