BDBM50156383 CHEMBL3785951

SMILES CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cc(OC[C@@H]3CCCO3)ccc2F)c2c(N)ncnc12

InChI Key InChIKey=YXLQJZQRBVGUCM-UHFFFAOYSA-N

Data  63 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 50156383   

TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 13nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CSK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKNK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 93nMAssay Description:Inhibition of full length insulin receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRKCQ (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAP3K8 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 12nMAssay Description:Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK5 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2A (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 175nMAssay Description:Inhibition of insulin receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRKACA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetActivin receptor type-1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACVR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 12nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKN1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cMET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AURKA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 16nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK4D1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VPS34 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 166nMAssay Description:Inhibition of full length insulin receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cKIT (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SRC (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ABL1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4Kbeta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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