BDBM50154397 CHEMBL3774760

SMILES OC(=O)CSc1ncnc2c(C3CC3)c(Cl)sc12

InChI Key InChIKey=LJYRIWUQISYYHA-UHFFFAOYSA-N

Data  4 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50154397   

TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  21nMAssay Description:Inhibition of human notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Mouse)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  55nMAssay Description:Inhibition of mouse notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human His6-tagged NOTUM (81 to 451 residues) Cys330Ser mutant transfected in HEK293S cells using OPTS as substrate incubated for 1 hr b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human Notum (S81-T451 residues) C330S mutant expressed in HEK293S cells using OPTS substrate incubated for 40 mins by fluorescence base...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of C-terminal His-tagged Notum (Ser81-Thr451 Cys330Ser) (unknown origin) using OPTS as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  23nMAssay Description:Inhibition of C-terminal His-tagged Notum (Ser81-Thr451 Cys330Ser) (unknown origin) assessed as restoration of Wnt/beta catenin signalling activated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataEC50:  23nMAssay Description:Inhibition of C-terminal His-V5 tagged human Notum expressed in human HEK293F cells harbouring TCF/LEF luciferase reporter gene assessed as activatio...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50154397(CHEMBL3774760)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Notum using OPTS substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)