BDBM50136608 CHEMBL3754069

SMILES OC(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)cc1

InChI Key InChIKey=FMPAHDTULKAUPN-UHFFFAOYSA-N

Data  12 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50136608   

TargetCoagulation factor XI(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataIC50: 26nMAssay Description:Inhibition of coagulation factor XIa (unknown origin) assessed as chromogenic substrate hydrolysis using CS-21(66) as substrate incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of plasma kallikrein (unknown origin) assessed as chromogenic substrate hydrolysis using CS-31(02) as substrate incubated for 1 hr by spec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor XI(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi:  2nMAssay Description:Inhibition of human coagulation factor 11a assessed as substrate hydrolysis to p-nitroaniline incubated for 10 to 120 mins by spectrophotometry analy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi:  122nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi:  5.20E+3nMAssay Description:Inhibition of human coagulation factor 10aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrypsin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >6.20E+3nMAssay Description:Inhibition of human trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition of human coagulation factor 7aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor XII(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of human coagulation factor 12aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of human urokinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKallikrein-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human tissue kallikreinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >4.60E+4nMAssay Description:Inhibition of human tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >6.40E+4nMAssay Description:Inhibition of human activated protein CMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor IX(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50136608(CHEMBL3754069)
Affinity DataKi: >7.30E+4nMAssay Description:Inhibition of human coagulation factor 9aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed