BDBM50134187 CHEMBL3735506::US11472795, Example C::US9611249, Compound 8

SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1

InChI Key InChIKey=QCLXNOBXQUWUEW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50134187   

TargetMitogen-activated protein kinase 7(Human)
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant ERK5 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant DYRK2 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 530nMAssay Description:Inhibition of human recombinant GRK2 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Angelini Acraf

US Patent
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 20nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Angelini Acraf

US Patent
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged GSK3beta (1 to 420 end residues) expressed in baculovirus expression system using u...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarizat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Angelini Acraf

US Patent
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 21.6nMAssay Description:The activity on human GSK-3β of the compounds of the invention listed in the following Table 1 and of the comparison compound C was assessed at ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US9611249, Compound 8 | US11472795...)
Affinity DataIC50: 49.9nMAssay Description:Confirmation of interaction with the potassium channels of the compounds of the invention listed in the following Table 1 and of the comparison compo...More data for this Ligand-Target Pair
In DepthDetails
US Patent