BDBM50117750 CHEMBL3586090

SMILES CC1(C)CN=C(S1)N1CCN(CC1)c1ncnc2sc(CC(F)(F)F)cc12

InChI Key InChIKey=SFDROHXKTATJBI-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117750   

TargetMenin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50117750(CHEMBL3586090)
Affinity DataIC50: 46nMAssay Description:Inhibition of N-terminal thioredoxin His6-tagged full-length human menin expressed in Escherichia coli Rosetta (DE3) cells assessed as reduction in m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMenin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50117750(CHEMBL3586090)
Affinity DataIC50: 190nMAssay Description:Inhibition of FITC-labelled MLL1 binding to menin (unknown origin) after 120 mins by fluorescence polarization methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)