BDBM50114590 5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL296103

SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCOCC1

InChI Key InChIKey=BCWVVERKADMJGG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50114590   

TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of TIE-2 kinase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Riken Center For Life Science Technologies

Curated by ChEMBL
LigandPNGBDBM50114590(5-(4-Phenoxy-phenyl)-7-(tetrahydro-pyran-4-yl)-7H-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human HCK (81 to 526 residues) expressed in Sf9 insect cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed