BDBM50113281 AT-7519::US20240293557, Compound AMC-3-098

SMILES Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1

InChI Key InChIKey=OVPNQJVDAFNBDN-UHFFFAOYSA-N

Data  9 KI  57 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 66 hits for monomerid = 50113281   

TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK9 (unknown origin) preincubated for 20 mins followed by [gamma-33P]ATP addition measured after 120 mins in presence of ATP by Hot-Sp...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 210nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 360nMAssay Description:Inhibition of CDK3/cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 210nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 89nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 4(Human)
Emory University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 6(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 2.06nMAssay Description:CDK9 activity assays were performed by Nanosyn using a microfluidics mobility shift platform. In this assay, a fluorescently labeled substrate is inc...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 3.90nMMore data for this Ligand-Target Pair
In DepthDetails

TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 27.4nMMore data for this Ligand-Target Pair
In DepthDetails

TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
L. M. College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK3beta (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP inc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of CDK7/cyclinH/MAT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged CDK1/human full-length N-terminal GST-tagged Cyclin B expressed in baculovirus inf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 513nMAssay Description:Inhibition of human recombinant full-length N-terminal His6-tagged CDK5/recombinant human full-length N-terminal GST-tagged p35 using biotinylated-hi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) using GST-tagged pRb (769 to 921 residues) as substrate measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK6/Cyclin D3 (unknown origin) using GST-tagged pRb (769 to 921 residues) as substrate measured after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full-length C-terminal His6-tagged CDK9/human full-length untagged cyclin T1 expressed in baculovirus infected Sf21 i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 360nMAssay Description:Inhibition of CDK3/cyclin E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 170nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) incubated for 30 mins in presence of ATP by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate measured after 4 hrs in presence of ATP by radiometric filter-binding assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098)
Affinity DataIC50: 210nMAssay Description:Inhibition of C-terminal His6-tagged human full length CDK1/N-terminal GST-tagged human full length cyclin B expressed in baculovirus infected Sf21 c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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