BDBM50111572 CHEMBL3605057
SMILES O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
InChI Key InChIKey=UKBGBACORPRCGG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50111572
Affinity DataIC50: 23nMAssay Description:Inhibition of TBK1 (unknown origin) incubated for 1 hr in presence of ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 23nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of AMPKalpha1/2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of IKKepsilon (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of MARK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of MARK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of MARK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of MARK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of GST fused recombinant SIK3 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of GST fused recombinant SIK2 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of GST fused recombinant SIK1 (unknown origin) expressed in HEK293 cells ALNRTSSDSALHRRR as substrate incubated for 1 hr in presence of AT...More data for this Ligand-Target Pair
Affinity DataIC50: 357nMAssay Description:Inhibition of TBK1 in human THP1-Blue ISG cells by measuring SEAP gene expression incubated for 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 421nMAssay Description:Inhibition of recombinant PDK1 (unknown origin) using PDK1tide substrate incubated for 7 minsMore data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 2(Human)
University of Science and Technology (Ust)
Curated by ChEMBL
University of Science and Technology (Ust)
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of NUAK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 319nMAssay Description:Displacement of tracer K5 from NLuc fused MARK4 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 328nMAssay Description:Displacement of tracer K9 from NLuc fused MARK3 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17A(Human)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Displacement of tracer K9 from NLuc fused DRAK1 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 251nMAssay Description:Binding affinity to TBK1 in human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
Affinity DataKd: 32nMAssay Description:Binding affinity to phosphorylated TBK1 in calyculin A stimulated human Ramos cell lysate incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
Affinity DataKd: 79nMAssay Description:Binding affinity to TBK1 in human HEK293/K562/placenta/HepG2 cell lysate mixture incubated for 45 mins by kinobeads based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of ULK2 (unknown origin) after 5 mins in presence of gamma-[32]P-ATP by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of wild type GST-tagged ULK1 (unknown origin) after 5 mins in presence of gamma-[32]P-ATP by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of GST-tagged ULK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of GST-tagged ULK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of SUMO-tagged ULK1 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubat...More data for this Ligand-Target Pair