BDBM50109551 (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID::(S)-2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-propionic acid::2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-propionic acid::2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-propionic acid(-) DRF 2725::CHEMBL24038::Ragaglitazar

SMILES CCO[C@@H](Cc1ccc(OCCN2c3ccccc3Oc3ccccc23)cc1)C(O)=O

InChI Key InChIKey=WMUIIGVAWPWQAW-UHFFFAOYSA-N

Data  2 KI  2 IC50  18 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50109551   

TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataIC50: 980nMAssay Description:Receptor binding affinity to human Peroxisome proliferator activated receptor alpha against [3H]-NNC 0061-4655 radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  575nMAssay Description:Transactivation of Homo sapiens (human) PPARgamma assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.24E+3nMAssay Description:Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at GAL4 fused human PPARalpha LBD (174 to 475 residues) expressed in HEK293T cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  570nMAssay Description:Agonist activity at GAL4 fused human PPARgamma LBD (174 to 475 residues) expressed in HEK293T cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at GAL4-fused PPARalpha assessed as transcriptional activity by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at GAL4-fused PPARgamma assessed as transcriptional activity by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  570nMAssay Description:Effective concentration against human peroxisome proliferator activated receptor gamma in Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.20E+3nMAssay Description:Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  575nMAssay Description:Transactivation of GAL4-fused Homo sapiens (human) PPARgamma DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonistic activity for Peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  600nMAssay Description:Agonistic activity for human Peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataIC50: 92nMAssay Description:Receptor binding affinity to human Peroxisome proliferator activated receptor gamma against [3H]ragalitazar radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  570nMAssay Description:In vitro activation of human peroxisome proliferator activated receptor gamma (PPAR gamma)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.21E+3nMAssay Description:In vitro activation of human peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  570nMAssay Description:In vitro transactivation using receptor transactivation assay against hPPAR gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.21E+3nMAssay Description:In vitro transactivation using receptor transactivation assay against hPPAR alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.21E+3nMAssay Description:Transactivation of GAL4-fused Homo sapiens (human) PPARalpha DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  575nMAssay Description:Transactivation of GAL4-fused Homo sapiens (human) PPARgamma DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article

TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataEC50:  3.21E+3nMAssay Description:Transactivation of GAL4-fused Homo sapiens (human) PPARalpha DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataKi:  90nMAssay Description:Binding affinity for human peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50109551(2-Ethoxy-3-[4-(2-phenoxazin-10-yl-ethoxy)-phenyl]-...)
Affinity DataKi:  980nMAssay Description:Binding affinity for human peroxisome proliferator activated receptor alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed