BDBM50099118 5-methyl-5-(4-phenoxyphenyl)barbituric acid::CHEMBL176467

SMILES CC1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=RTBMLCLTYAPKIF-UHFFFAOYSA-N

Data  3 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50099118   

TargetMatrix metalloproteinase-9(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 52nMAssay Description:Inhibition of Gelatinase B, matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 65nMAssay Description:Inhibition of collagenase-3, Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 81nMAssay Description:Inhibition of Gelatinase A, matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrilysin(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of matrilysin, Matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStromelysin-1(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNeutrophil collagenase(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 81nMAssay Description:Inhibition of human neutrophil collagenase-I, Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataKi:  52nMAssay Description:In vitro binding affinity against matrix metalloprotease 9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataKi:  65nMAssay Description:In vitro binding affinity against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target72 kDa type IV collagenase(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50099118(5-methyl-5-(4-phenoxyphenyl)barbituric acid | CHEM...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity against matrix metalloprotease 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed