BDBM50097398 CHEMBL449216::HTS-9026

SMILES NC(=O)c1nnc2ccccc2c1N

InChI Key InChIKey=FCYPWSQPDXUBPV-UHFFFAOYSA-N

Data  5 IC50  6 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50097398   

TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of MKK6 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to MKK3 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of Btk (unknown origin) assessed as inhibition of phosphorylation of FAM-labelled peptide substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of BMX (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase Nek10(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd:  430nMAssay Description:Inhibition of NEK10 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAngiopoietin-1 receptor(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of TIE2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd:  300nMAssay Description:Inhibition of YSK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed