BDBM50097393 CHEMBL3586447

SMILES Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(nnc12)C(N)=O

InChI Key InChIKey=PTHVKCSYXICMAR-UHFFFAOYSA-N

Data  17 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50097393   

TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant BtkMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataEC50:  101nMAssay Description:Reversible inhibition of sodium orthovanadate-stimulated BTK autophosphorylation at Tyr223 residues in human Ramos cells preincubated for 2 hrs follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 5.60nMAssay Description:Reversible inhibition of FAM-labeled peptide binding to full-length human N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus infe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant LynBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 82nMAssay Description:Inhibition of human recombinant LynAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 99nMAssay Description:Inhibition of human recombinant HckMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant FrkMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant BlkMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant BmxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant ItkMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant TecMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant FgrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataEC50:  28nMAssay Description:Inhibition of BTK autophosphorylation in human Raji cells after 30 mins by Phos-Y223 Btk HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 412nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetActivin receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant ALK2 by LanthaScreen Binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLIM domain kinase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant LIMK1 by LanthaScreen Binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant TNK2 by LanthaScreen Binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed