BDBM50089084 CHEMBL3317857::Vaborbactam

SMILES OB1O[C@H](CC(O)=O)CC[C@@H]1NC(=O)Cc1cccs1

InChI Key InChIKey=IOOWNWLVCOUUEX-UHFFFAOYSA-N

Data  3 KI  9 IC50

PDB links: 12 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50089084   

TargetTrypsin(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of trypsin (unknown origin) using N-Bz-R-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of plasmin (unknown origin) using H-D-VLK-pNA as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProthrombin(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of thrombin (unknown origin) using Benz-FVR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of urokinase (unknown origin) using NGK-pNA as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins by s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTissue-type plasminogen activator(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of tissue plasminogen activator (unknown origin) using GK-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChymase(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of chymase (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of dipeptidyl peptidase 7 (unknown origin) using H-Lys-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil elastase(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of neutrophil elastase (unknown origin) using MeOSuc-AAVP-AMC as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysosomal protective protein(Human)
Rempex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of cathepsin A (unknown origin) using MCA-RPPGFSAFK-Dnp as substrate preincubated for 10 mins followed by substrate addition measured for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbapenem-hydrolyzing beta-lactamase KPC(Klebsiella oxytoca)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataKi:  56nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Qpex Biopharma

Curated by ChEMBL
LigandPNGBDBM50089084(Vaborbactam | CHEMBL3317857)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed