BDBM50077325 2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one::3',4',7-trihydroxyflavon::7,3',4'-Trihydroxyflavone::CHEMBL301624

SMILES Oc1ccc2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1

InChI Key InChIKey=PVFGJHYLIHMCQD-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50077325   

TargetTelomerase reverse transcriptase(Human)
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 6.52E+3nMAssay Description:Inhibition of ALR2 (aldose reductase) of bovine lensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 870nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 630nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDNA polymerase eta(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50077325(7,3',4'-Trihydroxyflavone | 2-(3,4-dihydroxyphenyl...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of C-terminal 6xHis-tagged human DNA polymerase eta (1 to 511 residues) expressed in Escherichia coli BL21 DE3 using 5'-IRD700-GCAGGTCGACT...More data for this Ligand-Target Pair
In DepthDetails
PubMed