BDBM50075102 CHEMBL3414623

SMILES Cc1cn(CCN2CCN(CC2)c2ccccc2-c2cc(cc(c2)C(=O)NCCCN2CCCC2)C#N)c2ccccc12

InChI Key InChIKey=PNYRDVBFYVDJJI-UHFFFAOYSA-N

Data  454 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 454 hits for monomerid = 50075102   

TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl-GSRAHSSHLKSKKGQSTSRH as substrate after 75 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) using p53 (361 to 380) as substrate assessed as incorporation of tritium labeled methyl group from [3H]-SAM to p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) using p53(361-380) peptide as a substrate incubated for 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) using [3H]-p53 (361 to 380 residues) as substrate after 1 hr in presence of [3H]-SAM by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 15nMAssay Description:Inhibition of SMYD2 (unknown origin) using [H3]-SAM and p53 (361 to 380 residues) as peptide substrate incubated for 1 hr by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 17nMAssay Description:Inhibition of SMYD2 (unknown origin) using N-terminal GST-tagged MAP3K2 and 3H-SAM as substrate for 2 hrs by TopCount NXT plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 31nMAssay Description:Inhibition of SMYD2 (unknown origin) using [H3]-SAM and histone H4 as substrate incubated for 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 70nMAssay Description:Inhibition of SMYD2 (unknown origin) transfected in human U2OS cells assessed as inhibition of methylation of monomethyl p53 peptide incubated for 24...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 388nMAssay Description:Inhibition of SMYD2 (unknown origin) using H4 as substrate after 2hrs in presence 3H-SAM of by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 425nMAssay Description:Inhibition of SMYD2 (unknown origin) using 3H-SAM as substrate incubated for 1 hr by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 600nMAssay Description:Inhibition of FLAG-tagged SMYD2 (unknown origin) expressed in human U2OS cells mediated intracellular P53 methylation incubated for 15 hrs using p53 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 600nMAssay Description:Inhibition of FLAG-tagged SMYD2 (unknown origin) expressed in human KYSE-150 cells mediated intracellular P53 methylation at lysine 370 incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 600nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 600nMAssay Description:Inhibition of FLAG-tagged SMYD2 methylation co-transfected in human U2OS cells assessed as decrease in levels of p53 by measured after 15 hrs by cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 600nMAssay Description:Inhibition of SMYD2 in human KYSE-150 cells assessed as reduction of monomethylation of p53 K370 by sandwich ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 691nMAssay Description:Inhibition of SMYD2 in human HEK293T cells assessed as BTF3me1 levels by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FLAG-tagged SMYD2 methylation co-transfected in human HEK293 cells assessed as decrease in levels of p53 Lys370 me1 by Western blot ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetN-lysine methyltransferase SMYD2(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SMYD2 (unknown origin) using H4 as substrate after 2hrs in presence 3H-SAM of by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LXR-alpha by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ER-beta by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSteroid hormone receptor ERR1(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ER-alpha by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PPAR-gamma by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PPAR-delta by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PPAR-alpha by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LXR-beta by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RXR-alpha by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRetinoic acid receptor gamma(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RAR-gamma by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRetinoic acid receptor beta(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RAR-beta by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRetinoic acid receptor alpha(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RAR-alpha by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVitamin D3 receptor(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human VDR by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetThyroid hormone receptor beta(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TR-beta-1 by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetThyroid hormone receptor alpha(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TR-alpha-1 by Eurofins-CEREP pharmacology platform analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human DYRK1B by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of human PIP5K1A by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ACVR1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL2(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ABL2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ABL1 T315I mutant by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ABL1 Q252H mutant by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ACVRL1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivin receptor type-2B(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ACVR2B by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivin receptor type-2A(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ACVR2A by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivin receptor type-1B(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ACVR1B by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human AKT2 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human AKT1 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAtypical kinase COQ8B, mitochondrial(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ADCK4 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAtypical kinase COQ8A, mitochondrial(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ADCK3 by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ALKL1196M mutant by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ALKC1156Y mutant by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50075102(CHEMBL3414623)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ALK by discoverX kinome scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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