BDBM50073190 CHEMBL3408213::US11471446, Compound DBA-11
SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1
InChI Key InChIKey=LBFYQISQYCGDDW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50073190
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
The Institute of Cancer Research
Curated by ChEMBL
The Institute of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged TNKS1 (1023 to 1327 aa) (unknown origin) after 90 mins by HTRF assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
The Institute of Cancer Research
Curated by ChEMBL
The Institute of Cancer Research
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of GST-tagged TNKS2 (873 to 1166 aa) (unknown origin) after 90 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 462nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of ligand-induced WNT3A signaling in human PA-1 cells harboring TCF preincubated for 6 hrs before ligand addition measured after 24 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of CDK8 (unknown origin) assessed as inhibition rateMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...More data for this Ligand-Target Pair
Affinity DataKi: 231nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
Affinity DataKi: 345nMAssay Description:Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair