BDBM50068765 8-Methyl-2-(4-trifluoromethyl-phenyl)-3H-quinazolin-4-one::CHEMBL346886

SMILES Cc1cccc2c1nc([nH]c2=O)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=GDPZGQDEZJRADO-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50068765   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068765(8-Methyl-2-(4-trifluoromethyl-phenyl)-3H-quinazoli...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human tankyrase2 after 2 hrs by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068765(8-Methyl-2-(4-trifluoromethyl-phenyl)-3H-quinazoli...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human tankyrase1 after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068765(8-Methyl-2-(4-trifluoromethyl-phenyl)-3H-quinazoli...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IMPDH2 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Mouse)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068765(8-Methyl-2-(4-trifluoromethyl-phenyl)-3H-quinazoli...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM50068765(8-Methyl-2-(4-trifluoromethyl-phenyl)-3H-quinazoli...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PARP1 (unknown origin) after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed