BDBM50067678 (6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione::(6alpha)-6-methyl-3,20-dioxopregn-4-en-17-yl acetate::17-Acetoxy-6alpha-methylprogesterone::17alpha-Hydroxy-6alpha-methylprogesterone acetate::6-alpha-Methyl-17-alpha-acetoxyprogesterone::6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate::6alpha-Methyl-17-acetoxy progesterone::6alpha-Methyl-17alpha-hydroxyprogesterone acetate::6alpha-Methyl-4-pregnene-3,20-dion-17alpha-ol acetate::MEDROXYPROGESTERONE::Medroxyacetate progesterone::Medroxyprogesterone 17-acetate::Methylacetoxyprogesterone::Metigestrona::US9271961, MPA::medroxyprogesterone acetate
SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
InChI Key InChIKey=PSGAAPLEWMOORI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 50067678
Affinity DataIC50: 794nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human progesterone receptor in human T47D cells assessed as alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant AKR1C3 (unknown origin) assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant AKR1C1 expressed in Escherichia coli assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotome...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity against Human glucocorticoid receptor(hGR) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
Affinity DataEC50: 6.10nMAssay Description:Agonistic activity against Human androgen receptor(hAR) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 631nMAssay Description:Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulinMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
Affinity DataEC50: 6.10nMAssay Description:Effective concentration against Androgen receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Effective concentration against GR (glucocorticoid receptor)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Affinity DataIC50: 794nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Effective concentration on alkaline phosphatase activity in human T47D breast carcinoma cell line.More data for this Ligand-Target Pair
Affinity DataEC50: 6.10nMAssay Description:Effective concentration against Androgen receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Effective concentration against GR (glucocorticoid receptor)More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Effective concentration against PR (progesterone receptor)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor in human T47D cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 67.3nMAssay Description:Inhibitory progestational activity on oral administration in uterine C3 modelMore data for this Ligand-Target Pair
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) assessed as reduction in S-tetralol catalyzed oxidation in presence of NADPH by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of recombinant N-terminal His-tagged AKR1C3 (unknown origin) assessed as rate of change of pyridine nucleotide absorbance in presence of N...More data for this Ligand-Target Pair
Affinity DataKd: 1nMAssay Description:Agonist activity at human Androgen receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Binding affinity for Progesterone receptor (PR) in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of [3H]P4 to progesterone receptor (PR) of human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Inhibitory activity against progesterone receptor induced alkaline phosphatase activity in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibitory activity (IC50) against human androgen receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonistic activity to the human progesterone receptor (hPR)assayed in CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory activity (IC50) against human glucocorticoid receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity (IC50) against human mineralocorticoid receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Effective concentration against glucocorticoid receptor in human lung A549 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonistic activity against human progesterone receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonistic activity against human progesterone receptor in T47D breast cancer cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against human Mineralocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 6.10nMAssay Description:Effective concentration against Androgen receptor in mouse fibroblast L929 cellsMore data for this Ligand-Target Pair