BDBM50063698 4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester::4-Guanidino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester(FUT-175)::CHEMBL273264::Nafamostat
SMILES [#7]\[#6](-[#7])=[#7]/c1ccc(cc1)-[#6](=O)-[#8]-c1ccc2cc(ccc2c1)-[#6](-[#7])=[#7]
InChI Key InChIKey=QQRQFIXRVWJLNT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50063698
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of C1r serine proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human serum C1s using AGLME as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human serum C1r using AAME as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at integrin alpha2b beta3 receptor in citrated human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition of purified human C1r protease.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C1r serine proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Compound was evaluated for inhibitory activity against C1r serine protease. More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.11E+4nMAssay Description:Inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory concentration against cathepsinMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory concentration against plasminMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory concentration against thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Compound was evaluated for inhibitory activity against plasmin.More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Compound was evaluated for inhibitory activity against Thrombin.More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Compound was evaluated for inhibitory activity against C1s serine protease. More data for this Ligand-Target Pair
TargetIntegrin alpha-2/beta-3(Human)
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Curated by ChEMBL
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Antagonist activity against integrin alpha2bbeta3 in human platelet rich plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to crom...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Evaluated in vitro for inhibitory activity against purified human C1r protease incubated in buffer for 60 minutesMore data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Inhibition of HGFA in human MDA-MB-231 cells assessed as inhibition of c-MET phosphorylation after 15 mins by immunoblottingMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for inhibitory activity against Trypsin.More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:In vitro for inhibition of purified bovine trypsin.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:The compound was evaluated to inhibit 50% of Clr Serine Protease after 60 mins and is expressed in IC50 (uM).More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:The compound was evaluated to inhibit trypsin and is expressed in IC50 (The concentration required to inhibit 50% of the enzyme).More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using Cbz-Gly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Compound was evaluated for inhibitory activity against Kallikrein.More data for this Ligand-Target Pair
Affinity DataKi: 0.0200nMAssay Description:Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0200nMAssay Description:Inhibition of matriptase (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Inhibition of recombinant hepsin (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of recombinant HGFA (unknown origin) using Boc-QLR-AMC as substrate by chromogenic proteolytic assayMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...More data for this Ligand-Target Pair
Affinity DataKi: 105nMAssay Description:Inhibition of human factor 12a using chromogenic substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
Affinity DataKi: 410nMAssay Description:Inhibition of human plasmin assessed as reduction in hydrolytic activity using TAME as substrate after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair