BDBM50059190 CHEMBL3393333

SMILES FC1(F)CCN(C1)c1cc(cc(Nc2cc(ccn2)C#N)n1)C1CCN(CC1)C1COC1

InChI Key InChIKey=RHFIAUKMKYHHFA-UHFFFAOYSA-N

Data  2 KI  11 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50059190   

LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 30nMAssay Description:Inhibition of human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 129nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 514nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 364nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 68nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 767nMAssay Description:Inhibition of MLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 602nMAssay Description:Inhibition of MLK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 3nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase 13(Human)
Denali Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataIC50: 3nMAssay Description:Inhibition of LZK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataKi: <0.5nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein delta homolog 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)
Affinity DataKi: <0.5nMAssay Description:Binding affinity to DLK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed