BDBM50052398 (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid::(2R,4R)-APDC::2R, 4R-APDC::CHEMBL40086

SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O

InChI Key InChIKey=XZFMJVJDSYRWDQ-UHFFFAOYSA-N

Data  10 KI  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50052398   

TargetMetabotropic glutamate receptor 2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  200nMAssay Description:Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  1.00E+5nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  1.10E+5nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  2.00E+5nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails Article

TargetMetabotropic glutamate receptor 3(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  1.70E+3nMAssay Description:Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  300nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article

TargetMetabotropic glutamate receptor 2(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  480nMAssay Description:Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi:  410nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi:  450nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor 3(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi:  2.73E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi:  3.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi:  1.10E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed