BDBM50050549 GSK2140944::Gepotidacin
SMILES O=c1ccc2ncc(=O)n3[C@H](CN4CCC(CC4)NCc4cc5CCCOc5cn4)Cn1c23
InChI Key InChIKey=PZFAZQUREQIODZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50050549
Affinity DataIC50: 374nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana
Curated by ChEMBL
University of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 relaxation activity measured for 30 minsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana
Curated by ChEMBL
University of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 244nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Ljubljana
Curated by ChEMBL
University of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 374nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 5.52E+4nMAssay Description:Inhibition of human topoisomerase 2 assessed as reduction in decatenationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by Ionworks electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Staphylococcus aureus Gyrase supercoiling activity assessed as reduction in supercoiling pBR322 DNA by measuring relaxation by bromophe...More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using positively supercoiled pBR322 DNA as substrate incubated for 25 mins by ethidium bromide stainin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+6nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4More data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+6nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+6nMAssay Description:Inhibition of human ERG expressed in CHO cells using -80 mV holding potential measured after 3 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair