BDBM50050083 CHEMBL3317833::US9216988, 101

SMILES CC(C)CN(Cc1ccc(cc1)N1CCN(CC1)C(C)=O)S(=O)(=O)Cc1ccccc1

InChI Key InChIKey=CYRKYCCPWKLCDV-UHFFFAOYSA-N

Data  1 IC50  8 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50050083   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataIC50: 47nMpH: 7.4Assay Description:On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash buff...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50:  57nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50:  120nMAssay Description:Agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human RORb expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-g...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor ROR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50: >1.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused human RORa expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human FXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human LXRalpha expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dua...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human LXRbeta expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50050083(US9216988, 101 | CHEMBL3317833)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused human PXR expressed in HEK293T cells assessed as activation of basal transcriptional activity after 20 hrs by dual-glo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed