Affinity DataEC50: 7nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic)More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Functional potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)More data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Functional potency for nAChR subtype Alpha-1-beta-1-delta gamma (torpedo)More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
Affinity DataEC50: 0.0370nMAssay Description:Effective concentration in KXalpha-3-beta-4R2 cells expressing rat nicotinic acetylcholine receptor alpha3-beta4 subunitsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0530nMAssay Description:Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptorsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.00880nMAssay Description:Change in membrane potential in K-177 cells expressing acetylcholine central neuronal receptor alpha4-beta2 subunits More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
Affinity DataKd: 0.0400nMAssay Description:Dissociation constant against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
Affinity DataKd: 0.300nMAssay Description:Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
Affinity DataKd: 0.0300nMAssay Description:Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
Affinity DataKd: 1.06nMAssay Description:Dissociation constant for nicotinic acetylcholine receptor alpha 7 from human neuroblastoma SH-SY5Y cells; n=3More data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at rat alpha3beta4 nAChR expressed in HEK292 cells assessed as increase of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+3nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Functional activation of human sympathetic ganglionic type nAChRs in IMR-32 cells containing alpha-3 subtypeMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at alpha-4-beta-2 in IMR-32cells assessed as calcium influx by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity at recombinant human alpha-4-beta-2 nAChR expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 128nMAssay Description:Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:In vitro displacement of [3H]oxotremorine-M from muscarinic acetylcholine receptor in rat brain cortexMore data for this Ligand-Target Pair
Affinity DataKd: 0.0800nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
Affinity DataKd: 0.0300nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta2More data for this Ligand-Target Pair
Affinity DataKd: 0.300nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
Affinity DataKd: 0.0200nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2More data for this Ligand-Target Pair
Affinity DataKd: 0.0400nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
Affinity DataKd: 0.0900nMAssay Description:Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human alpha4beta2 nAChR by cell-based rubidium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 41nMAssay Description:Agonist activity at rat alpha3beta4 nAChR by cell-based rubidium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at alpha-3-beta-4 nAChR in KXalpha-3-beta-4R2 cells by rubidium efflux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 700nMAssay Description:Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor (nAChR) expressed in IMR32 cell More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:In vitro binding affinity by inhibiting [3H]dopamine release in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:In vitro binding affinity by inhibiting [3H]dopamine release in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0370nMAssay Description:Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylc...More data for this Ligand-Target Pair
Affinity DataKd: 6.30nMAssay Description:Displacement of [3H]epibatidine from chimeric human alpha7-5-HT3A receptor expressed in HEK293 cells after 2 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.00800nMAssay Description:In vitro binding affinity towards (alpha-4)2(beta-2)3 neuronal nicotinic acetylcholine receptor in P2 membrane fractions of rat forebrainMore data for this Ligand-Target Pair
Affinity DataKi: 0.00900nMAssay Description:Ability of compound to compete with 50 pM of 5-[125I]iodo-A-85,380 for receptor binding sites in rat brain membranes at room temperatureMore data for this Ligand-Target Pair