BDBM50046657 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one::CHEMBL320775

SMILES Cc1ccc2nc(N)[nH]c(=O)c2c1Sc1ccncc1

InChI Key InChIKey=XHWRWCSCBDLOLM-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50046657   

TargetThymidylate synthase(Human)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046657(2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quina...)
Affinity DataKi:  15nMAssay Description:Inhibition of human Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Human)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046657(2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quina...)
Affinity DataKi:  16nMAssay Description:Inhibition of human Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046657(2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quina...)
Affinity DataKi:  49nMAssay Description:Inhibition of purified Escherichia coli Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThymidylate synthase(Escherichia coli)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50046657(2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quina...)
Affinity DataKi:  140nMAssay Description:Inhibition of purified Escherichia coli Thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed