BDBM50035558 5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline::CHEMBL310238

SMILES Fc1ccccc1C1=Cc2ccccc2C2=NCCN12

InChI Key InChIKey=CRASKXTVWBAFRS-UHFFFAOYSA-N

Data  2 IC50  3 Kd

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50035558   

TargetPlatelet-activating factor receptor(Human)
Sandoz Research Institute

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of [3H]PAF binding to human platelet activating factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataIC50: 6.04E+3nMAssay Description:Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolycomb protein EED(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd:  1.35E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant b...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed