BDBM50035235 CHEMBL2372437::N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydroxy-2-isobutyl-malonamide

SMILES CC(C)C[C@H](C(=O)NO)C(=O)N[C@@H](C)C(=O)NCC(N)=O

InChI Key InChIKey=FGSNBBSHVNLDMX-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50035235   

TargetThermolysin(Bacillus thermoproteolyticus)
TBA

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 64nMAssay Description:Compound was tested in vitro for inhibitory activity against thermolysinMore data for this Ligand-Target Pair
In DepthDetails Article

TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin-converting enzyme 1(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
TBA

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 175nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeprilysin(Rabbit)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
TBA

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataKi:  478nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeutrophil collagenase(Human)
Institut FüR Biochemie

Curated by ChEMBL
LigandPNGBDBM50035235(N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''-hydrox...)
Affinity DataKi:  1.21E+5nMAssay Description:Inhibition of Matrix metalloprotease-8 (Human neutrophil collagenase, MMP-8)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed