BDBM50035218 CHEMBL61::PODOFILOX::Podophyllinic acid lactone::Podophyllotoxin (PTOX)::podophyllotoxin
SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12
InChI Key InChIKey=YJGVMLPVUAXIQN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 50035218
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibition of purified bovine brain tubulin polymerisation in the absence of microtubule-associated proteins.More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Ability to inhibit Tubulin polymerization in Bovine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees CMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of tubulin polymerization using isolated calf brainMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Concentration inhibiting tubulin polymerization (ITP)More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization by GTP-induced assemblyMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of tubulin polymerization in porcine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of bovine brain tubulin polymerization (ITP).More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Binding affinity to pig brain tubulin at 10 uM after 15 mins relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.71E+3nMAssay Description:Competitive binding affinity to pig brain tubulin colchicine binding site after 1 hr by mass spectrophotometric analysis in presence of colchicineMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of pig tubulin polymerization determined after 45 mins at 37 degC by turbidimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry analysisMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentrationMore data for this Ligand-Target Pair
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 45.4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro activity assay using leishmania tarentolae and porcine brain tubulin.More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 0 group B member 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetNuclear receptor subfamily 0 group B member 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine
Affinity DataIC50: 2.50E+4nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...More data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of tubulin polymerization. (ITP)More data for this Ligand-Target Pair
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 81nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 830nMAssay Description:Inhibition of bovine brain tubulin polymerization by fluorescence analysisMore data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 1a)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: 2.41E+4nMAssay Description:Binding affinity to HPV1a recombinant E2 protein by surface plasmon resonance methodMore data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 1a)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: >4.00E+5nMAssay Description:Binding affinity to HPV1a recombinant E2 protein activator domain by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 1a)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: 1.05E+3nMAssay Description:Binding affinity to HPV1a recombinant E2 protein hinge domain by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 1a)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: >4.00E+5nMAssay Description:Binding affinity to HPV1a recombinant E2 protein DNA binding domain by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 11)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: 2.01E+4nMAssay Description:Binding affinity to HPV11 recombinant E2 protein by surface plasmon resonance methodMore data for this Ligand-Target Pair
TargetRegulatory protein E2(Human papillomavirus type 16)
Tokyo University of Science
Curated by ChEMBL
Tokyo University of Science
Curated by ChEMBL
Affinity DataKd: 7.05E+4nMAssay Description:Binding affinity to HPV16 recombinant E2 protein by surface plasmon resonance methodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Sheep)
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
Affinity DataKi: 2.18E+3nMAssay Description:Binding affinity against tubulin using [3H]colchicine as radioligandMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 50035218
ITC DataΔG°: -260kcal/mole −TΔS°: -74.6kcal/mole ΔH°: -185kcal/mole logk: 8.82E+3
T: 30.00°C
T: 30.00°C