BDBM50035179 Agomelatine::CHEMBL10878::N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide::N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide(Agomelatine)::S 20098::US10781182, Compound IA2-76::US11091445, Compound code IA2-76::US11980598, Compound Ago
SMILES COc1ccc2cccc(CCNC(C)=O)c2c1
InChI Key InChIKey=YJYPHIXNFHFHND-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 73 hits for monomerid = 50035179
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.100nMAssay Description:Binding affinity to melatonin receptor measured on ovine pars tuberalis membraneMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 0.180nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1BMore data for this Ligand-Target Pair
Affinity DataEC50: 1.56nMAssay Description:Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.52nMAssay Description:The test tubes were placed under a reaction condition of 25° C. 50 μg of the receptor membrane protein 5-HT2C was added to all the tubes. In non...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.180nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Functional activity against melatonin receptor in lightening Xenopus laevis tadpole skinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:The test tubes were placed in a reaction condition of 25° C. 10 μL of receptor membrane protein MT1 or MT2 was added to all the tubes. In non-sp...More data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMAssay Description:The test tubes were placed in a reaction condition of 25° C. 10 μL of receptor membrane protein MT1 or MT2 was added to all the tubes. In non-sp...More data for this Ligand-Target Pair
Affinity DataEC50: 8.89E+4nMAssay Description:Agonist activity at human MT2 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-be...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.65E+4nMAssay Description:Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-be...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80E+6nMAssay Description:Agonist activity at human MT1 receptor expressed in HEK293 cells by Fluo-8 based calcium assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.73E+7nMAssay Description:Agonist activity at human MT2 receptor expressed in HEK293 cells by Fluo-8 based calcium assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0761nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0600nMAssay Description:Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as rad...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Pig)
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.100nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Binding affinity against ovine pars tuberalis melatonin receptor using 2-[125I]- melatonin radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Pig)
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Glaxo Wellcome Research and Development
Curated by PDSP Ki Database
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair