BDBM50031612 CHEMBL3354688

SMILES CC(C)(C)COc1ccc2Oc3ccc(cc3[C@@]3(COC(N)=N3)c2c1)-c1cncnc1

InChI Key InChIKey=CHZHWZAKWGFQNL-UHFFFAOYSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50031612   

TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin) assessed as enhancement of fluorescence intensityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 25nMAssay Description:Inhibition of BACE1 in HEK293T cells expressing APPswedish mutant assessed as inhibition of amyloid beta 40 production by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin D(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCathepsin E(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 320nMAssay Description:Inhibition of cathepsin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 25nMAssay Description:Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 15nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRenin(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataKi:  660nMAssay Description:Inhibition of human ERG expressing HEK293 cells by [3H]dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataKi:  660nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50031612(CHEMBL3354688)
Affinity DataKi:  660nMAssay Description:Binding affinity to human ERG assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed