BDBM500288 US11021475, Example 52::US11021475, Example 67::US11578058, Compound Reference (BMS-986165)::US11731956, Example control::US20240101548, Compound BMS-986165::US20240246944, Control (BMS-986165)
SMILES CNC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
InChI Key InChIKey=BZZKEPGENYLQSC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 500288
Affinity DataIC50: 3.00E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 5.90nMAssay Description:Assays were performed in 384-well plates with a final assay volume of 20 μL containing copper-polyvinyltoluene scintillation proximity assay (SP...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 0.140nMAssay Description:Compound of the present invention formulated into different concentrations (series 3 times dilutions, started from 60 μM, 11 concentrations in t...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 5.5nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 2.90E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 840nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 5.70nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataEC50: 5.13nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 5.60nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Anrui Biomedical Technology (Guangzhou) Co., Ltd.
US Patent
Affinity DataIC50: 2.10E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
Affinity DataKd: 5.50E+3nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
Affinity DataEC50: 6.53nMAssay Description:The probe displacement assay is conducted as follows: In a 385 well plate, test compounds along with recombinantly expressed His-tagged protein corre...More data for this Ligand-Target Pair