BDBM50020192 8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL300555::Spiroxatrine

SMILES O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccccc3O2)CC1

InChI Key InChIKey=JVGBTTIJPBFLTE-UHFFFAOYSA-N

Data  51 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 50020192   

TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataEC50:  3.55E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataEC50:  2.00E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataEC50:  2.51E+4nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.260nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(North American opossum)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.260nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.280nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.290nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.590nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(North American opossum)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.610nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(North American opossum)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.670nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.840nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.04nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.45nMAssay Description:Binding affinity against Dopamine receptor D2 of rat was determined using 2 nM of [3H]sulpiride in binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against Dopamine receptor D2 of rat was determined using 2 nM of [3H]sulpiride in binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.57nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.81nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rabbit)
University of Montana

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Pig)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  3.36nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  5.5nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  7.41nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  8.30nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  8.31nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  9.33nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  9.54nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  12.0nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  21nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat was determined using [3H]8-OH-DPAT in binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  21nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor of rat was determined using [3H]8-OH-DPAT in binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  28.3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  54.3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  68nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  70nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  92nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(Rabbit)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  129nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2B adrenergic receptor(Rabbit)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  169nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  173nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  193nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  475nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  505nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  858nMAssay Description:Binding affinity towards serotonin 5-hydroxytryptamine 2 receptor of rat determined using 0.5 nM of [3H]ketanserin in binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  858nMAssay Description:Binding affinity towards serotonin 5-hydroxytryptamine 2 receptor of rat determined using 0.5 nM of [3H]ketanserin in binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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