BDBM50019848 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole::4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole::CHEMBL10316::Idazoxan::US8633208, Idazoxan

SMILES C1CN=C(N1)C1COc2ccccc2O1

InChI Key InChIKey=HPMRFMKYPGXPEP-UHFFFAOYSA-N

Data  71 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 84 hits for monomerid = 50019848   

LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Rottapharm

US Patent
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase acti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Rottapharm

US Patent
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase acti...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of specific binding of [3H]-YM 09151-2 to Dopamine receptor D2 site in rat striatal tissue.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 54nMAssay Description:Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 8.30nMAssay Description:Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 2.88E+3nMAssay Description:Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 19nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.02nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.5nMAssay Description:Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.63nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity at Alpha-2 adrenergic receptor in rat cortex by radioligand binding assay using [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(North American opossum)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Guinea pig)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Barcelona

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in post-mortem human brain frontal cortex membrane measured after 30 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.60nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.90nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNischarin(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  9.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  9.77nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  10nMAssay Description:Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]clonidine from rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]clonidine from alpha-2 adrenergic receptor in rat brain homogenates in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-clonidine from alpha-1 adrenergic receptor in rat brain homogenates in vitroMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha-2 adrenergic receptor determined by measurement of [3H]yohimbine displacement from rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat cerebral cortical membrane, determined using [3H]- yohimbine as the radioligand.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-1D adrenergic receptor(Mouse)
Smith Kline & French Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  19.9nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Janssen Research Foundation

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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