BDBM50019040 CHEMBL1230001

SMILES OC(=O)c1ccccc1NC(=O)N1CCC(CC1)c1ccccc1C(F)(F)F

InChI Key InChIKey=MEAQCLPMSVEOQF-UHFFFAOYSA-N

Data  11 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50019040   

TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 89nMAssay Description:Displacement of [3H]-retinol from human recombinant RBP4 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant RBP4-transthyretin interaction by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 0.155nMAssay Description:Antagonist activity at maltose binding protein-tagged RBP4 (unknown origin) expressed in Escherichia coli assessed as inhibition of retinol-induced p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]retinol from biotinylated human RBP4 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C9(Human)
Albany Molecular Research

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Albany Molecular Research

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Albany Molecular Research

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Albany Molecular Research

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]-retinol from RBP4 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 122nMAssay Description:Inhibition of retinol-induced interaction of bacterially expressed MBP-tagged RBP4 (unknown origin) with Eu3+ cryptate labeled TTR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRetinol-binding protein 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50019040(CHEMBL1230001)
Affinity DataIC50: 15nMAssay Description:Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)