BDBM50007789 CHEMBL1173044::GRL-0667::N-(2H-1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide (I-3)::med.21724, Compound 165

SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1ccc2OCOc2c1)c1cccc2ccccc12

InChI Key InChIKey=IVXBCFLWMPMSAP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50007789   

TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 980nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetORF1a(Middle East respiratory syndrome coronavirus (Viru...)
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 1.20E+3nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGenome polyprotein(HCV)
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydroorotase(Bacillus anthracis)
University of Illinois At Chicago

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 1.00E+5nMpH: 7.5Assay Description:The fluorogenic substrate used in this study was ubiquitin-AMC (Boston Biochem). All assays were performed in 384-well black plates (Corning) in a to...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human USP8 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human USP21 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(HCoV-NL63)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: 320nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed