BDBM50004656 (2-Carbamoyloxy-ethyl)-trimethyl-ammonium::(2-Carbamoyloxyethyl)trimethylammonium chloride::(2-Hydroxyethyl)trimethyl ammonium chloride carbamate::(2-Hydroxyethyl)trimethylammonium chloride carbamate::(carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride::2-(carbamoyloxy)-N,N,N-trimethylethanaminium::2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride::CARBACHOL::CARBASTAT::CHEMBL14::Carbachol chloride::Carbamylcholine::Choline carbamate chloride::Choline chloride, carbamate::Choline chlorine carbamate::Karbachol::Karbamoylcholin chlorid::MIOSTAT
SMILES C[N+](C)(C)CCOC(N)=O
InChI Key InChIKey=VPJXQGSRWJZDOB-UHFFFAOYSA-O
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 279 hits for monomerid = 50004656
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKd: 1.82E+4nMAssay Description:Muscarinic acetylcholine receptor M3 agonistic/antagonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+4nMAssay Description:Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+3nMAssay Description:In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropineMore data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 4.60E+3nMAssay Description:In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (...More data for this Ligand-Target Pair
Affinity DataEC50: 360nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+3nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected...More data for this Ligand-Target Pair
Affinity DataEC50: 650nMAssay Description:Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscari...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPMore data for this Ligand-Target Pair
Affinity DataEC50: 6.10E+4nMAssay Description:Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+4nMAssay Description:Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell lineMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:M2 agonist activity estimated by depression of isolated guinea pig left atriumMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+5nMAssay Description:In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
Affinity DataIC50: 4.09E+3nMAssay Description:Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+5nMAssay Description:Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
Affinity DataEC50: 6.00E+4nMAssay Description:Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M4More data for this Ligand-Target Pair
Affinity DataEC50: 8.90E+3nMAssay Description:Agonistic activity against muscarinic acetylcholine receptor M5 expressed in NIH 3T3 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity against M4 muscarinic receptor expressed in RBL-2H3 Mast cells.More data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+5nMAssay Description:Agonistic activity against M1 muscarinic receptor expressed in NIH 3T3 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+4nMAssay Description:Agonistic activity against M1 muscarinic receptor expressed in A9 L cells.More data for this Ligand-Target Pair
Affinity DataEC50: 1.86E+4nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.61E+3nMAssay Description:Agonist activity at human M4 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayMore data for this Ligand-Target Pair
Affinity DataEC50: 155nMAssay Description:Agonist activity at human M4 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.29E+3nMAssay Description:Agonist activity at human M4 receptor expressed in HEK293T cells by BRET based beta-arrestin engagement assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.59E+3nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein engagement assayMore data for this Ligand-Target Pair
Affinity DataEC50: 631nMAssay Description:Agonist activity at human M1 receptor expressed in HEK293T cells by BRET based Gq protein activation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.46E+3nMAssay Description:Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (R...More data for this Ligand-Target Pair
Affinity DataEC50: 1.06E+4nMAssay Description:Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human mus...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 1.89E+4nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)More data for this Ligand-Target Pair
Affinity DataIC50: 4.44E+4nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...More data for this Ligand-Target Pair
Affinity DataEC50: 3.35E+4nMAssay Description:Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90E+3nMAssay Description:Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
Affinity DataEC50: 2.80E+3nMAssay Description:Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
Affinity DataEC50: 700nMAssay Description:Stimulation of cAMP in CHO cells expressing human m2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.81E+3nMAssay Description:Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]-NMS radioligand using membranes in transfecte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfect...More data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+4nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]-NMS radioligand using membranes from tran...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
Affinity DataEC50: 9.90E+3nMAssay Description:Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell lineMore data for this Ligand-Target Pair