BDBM50002341 CHEMBL442384

SMILES Nc1nc2ccc(cc2s1)C(F)(F)F

InChI Key InChIKey=WEDYEBJLWMPPOK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50002341   

TargetBifunctional epoxide hydrolase 2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50002341(CHEMBL442384)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50002341(CHEMBL442384)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of human Nav 1.4 expressed in HEK293T cells assessed as tonic block at 0.1 Hz by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50002341(CHEMBL442384)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of human Nav 1.4 expressed in HEK293T cells assessed as phasic block at 10 Hz by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed