BDBM50001775 (ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1H-indolizin-5-one::(ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one::6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one (Ritanserin)::6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(Ritanserin)::CHEMBL267777::RITANSERIN::Ritanserine::cid_5074
SMILES [#6]-c1nc2sccn2c(=O)c1-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\c1ccc(F)cc1)-c1ccc(F)cc1
InChI Key InChIKey=PSHRUZSIXFFMHV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 139 hits for monomerid = 50001775
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0690nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Compound was tested for the displacement of [3H]prazosin from alpha-1 adrenergic receptor of rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Compound was tested for the displacement of [3H]spiperone from dopamine receptor D2 from rat striatal membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Compound was tested for i the displacement of [3H]prazosin from alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Compound was tested for the displacement of [3H]spiperone from dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity at dopamine D2 receptor by [3H]spiperone displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity to dopamine receptor D2 using a [3H]-spiperone binding assay in rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Binding affinity to serotonin 5-hydroxytryptamine 2A receptors using a radioligand [3H]ketanserin binding assay in rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of [3H]spiperone binding to 5-hydroxytryptamine 2 receptor from rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Compound was tested for the displacement of [3H]ketanserin from serotonin 5-hydroxytryptamine 2 receptor from rat cortical membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Compound was tested for the displacement of [3H]ketanserin from serotonin 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [ga...More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [ga...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human DGK alpha using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase beta(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK beta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase gamma(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK gamma using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase zeta(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK zeta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase iota(Homo sapiens)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DGK iota using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of DGK alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0830nM ΔG°: -12.8kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...More data for this Ligand-Target Pair
Affinity DataKi: 0.440nM ΔG°: -11.9kcal/moleT: 2°CAssay Description:For the membrane binding, NIH-3T3 cells were grown to 70% confluence in 15-cm2 dishes and transfected with 10 ug of receptor plasmid DNA using Polyfe...More data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Binding affinity to 5-HT2A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.610nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2 receptor in rat striatal membranes by [3H]ketanserin displacement.More data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Binding affinity was evaluated in vitro by displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor on rat cortical membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Binding constant against 5-hydroxytryptamine 2 receptor (in vitro)More data for this Ligand-Target Pair