BDBM50000334 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one::6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one(BL-4162A)::6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one(anagrelide)::ANAGRELIDE::Agrylin::CHEMBL760

SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl

InChI Key InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N

Data  10 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50000334   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataEC50:  1.05E+3nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of cGMP hydrolysis by human platelet phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human blood platelet c-AMP phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 80nMAssay Description:In vitro inhibition of cyclic AMP phosphodiesterase from human platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 80nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 50nMAssay Description:Inhibition of hydrolysis of c-AMP phosphodiesterase in human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataEC50:  1.05E+3nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Baruch S. Blumberg Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant PDE3 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The Baruch S. Blumberg Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed