BDBM4622 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol::Anilinoquinazoline deriv. 5::CHEMBL127907
SMILES COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
InChI Key InChIKey=BNDYIYYKEIXHNK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 4622
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Institute of Research
Curated by ChEMBL
Institute of Research
Curated by ChEMBL
Affinity DataIC50: 1.68E+5nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair
Affinity DataIC50: 4.61E+3nMAssay Description:Inhibition of GST-tagged TTBK1 (1 to 421) (unknown origin) using DNA Topoisomerase 2-alpha-Thr1342 as substrate incubated for 15 mins followed by ATP...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 240nMAssay Description:Binding affinity to CM5 sensor chip immobilized C-terminal His6/TEV fused-GST-tagged human TTBK1 (14 to 313 residues) expressed in baculovirus infect...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of VEGFR2 (unknown origin) by caliper mobility shift assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 240nMAssay Description:Binding affinity to phosphorylated TTBK1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Technical University of Madrid
Curated by ChEMBL
Technical University of Madrid
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of FLT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Cdk2More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
TargetVascular endothelial growth factor receptor 1(Human)
Technical University of Madrid
Curated by ChEMBL
Technical University of Madrid
Curated by ChEMBL
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based lumine...More data for this Ligand-Target Pair
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester
Curated by ChEMBL
University of Manchester
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
Affinity DataKd: 2.40E+3nMAssay Description:Equilibrium binding constant for EPH receptor B2More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 50nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair