BDBM449976 US10703755, Example 94

SMILES CCOc1nc(N)c2nc(-c3cncc(F)c3)n(Cc3ccc(CN4C[C@@H]5C[C@H]4CN5C)cc3)c2n1

InChI Key InChIKey=NHZSWKDFGUWVJJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 449976   

TargetToll-like receptor 7(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM449976(US10703755, Example 94)
Affinity DataIC50: 20nMAssay Description:As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter HEK293 cell), which is human embr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetToll-like receptor 7(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM449976(US10703755, Example 94)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at R848 stimulated TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated with comp...More data for this Ligand-Target Pair
In DepthDetails
PubMed