BDBM445033 US10668167, Compound 41

SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1C[C@H]1O[C@H](O[C@@]21C(=O)CO)c1ccc(Cc2cccc(N)c2)cc1

InChI Key InChIKey=MPEPSOPXQDGEHP-UHFFFAOYSA-N

Data  9 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 445033   

TargetGlucocorticoid receptor(Human)
Abbvie

US Patent
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 2.80nMAssay Description:Small molecules were tested for glucocorticoid receptor (GR) binding using the Polarscreen Glucocorticoid Receptor Assay Kit, Red (ThermoFisher A 158...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetProgesterone receptor(Human)
Abbvie

US Patent
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 76nMAssay Description:Small molecules were tested for progersterone receptor (PR) binding using a modification of the LanthaScreen TR-FRET Progesterone Receptor Coactivato...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEstrogen receptor(Human)
Abbvie

US Patent
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 3.00E+4nMAssay Description:Small molecules were tested for estrogen receptor (ER) alpha binding using a modification of the LanthaScreen TR-FRET Estrogen Receptor Alpha Coactiv...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAndrogen receptor(Human)
Abbvie

US Patent
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 3.00E+4nMAssay Description:Small molecules were tested for androgen receptor (AR) binding using a modification of the LanthaScreen TR-FRET Androgen Receptor Coactivator Assay (...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlucocorticoid receptor(Human)
Abbvie

US Patent
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 3nMAssay Description:Inhibition of glucocorticoid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Abbvie

US Patent
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataEC50:  3nMAssay Description:Agonist activity at glucocorticoid receptor (unknown origin) expressed in K562 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1A2(Human)
Abbvi

Curated by ChEMBL
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2C9(Human)
Abbvi

Curated by ChEMBL
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2D6(Human)
Abbvi

Curated by ChEMBL
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 3A4(Human)
Abbvi

Curated by ChEMBL
LigandPNGBDBM445033(US10668167, Compound 41)
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed