BDBM432484 N-(1-((2-aminoethyl)sulfonyl)piperidin-4- yl)-5-cyclopropylisoxazole-3-carboxamide::US10577363, Compound 183

SMILES NCCS(=O)(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=AMCHZZBLDUVCGF-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 432484   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM432484(N-(1-((2-aminoethyl)sulfonyl)piperidin-4- yl)-5-cy...)
Affinity DataIC50: 1.42E+3nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM432484(N-(1-((2-aminoethyl)sulfonyl)piperidin-4- yl)-5-cy...)
Affinity DataIC50: 398nMAssay Description:Inhibition of recombinant N-terminal FLAG/His-tagged SMYD3 (unknown origin) expressed in baculovirus infected insect cells using 3H-SAM as substrate ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)